In early 2024, the European Space Agency officially adopted the LISA mission (Laser Interferometer Space Antenna) as the world’s first space-based gravitational wave observatory, with its launch set for 2035. LISA will provide a revolutionary view into the Universe by capturing gravitational waves in a frequency range inaccessible to ground-based detectors, allowing scientists to study entirely new astrophysical phenomena. As LISA opens this unexplored window, it poses exciting challenges for the astrophysics community, which must now focus on identifying the scientific questions that LISA will answer and developing the tools to do so. From November 5 to 7, 2024, more than a 100 researchers will gather at the Max Planck Institute for Astrophysics (MPA) in Garching bei München to participate in the LISA Astrophysics Working Group Meeting, where they will explore how LISA can deepen our understanding of black holes, stars, galaxies, and other astrophysical objects across the Universe.